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ResearchIn-Press PreviewGeneticsOncology Open Access | 10.1172/JCI178915
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Barata, P. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Gulati, S. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Elliott, A. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Hammers, H. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Burgess, E. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Gartrell, B. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Darabi, S. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Bilen, M. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Basu, A. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Geynisman, D. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Dawson, N. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Zibelman, M. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Zhang, T. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Wei, S. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Ryan, C. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Heath, E. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by Poorman, K. in: JCI | PubMed | Google Scholar
1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
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1Department of Internal Medicine, University Hospitals Seidman Cancer Center, Cleveland, United States of America
2Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, United States of America
3Clinical and Translational Research/Medical Affairs, Caris Life Sciences, Irving, United States of America
4UT Southwestern Kidney Cancer Program, UT Southwestern Medical Center, Dallas, United States of America
5Department of Internal Medicine, Levine Cancer Institute Atrium Health, Charlotte, United States of America
6Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Bronx, United States of America
7Clinical Genomics, Hoag Memorial Hospital Presbyterian, Newport Beach, United States of America
8Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America
9Department of Medical Oncology, University of Alabama, Birmingham, United States of America
10Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, United States of America
11Department of Internal Medicine, Georgetown University Lombardi Comprehensive Cancer Center, Washington D.C., United States of America
12Department of Internal Medicine, Fox Chase Cancer Center, Philadelphia, United States of America
13Department of Pathology, Fox Chase Cancer Center, Philadelphia, United States of America
14Medical School, University of Minnesota, Minneapolis, United States of America
15Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, United States of America
16Department of Molecular Biology, Caris LifeSciences, Irving, United States of America
17Chairman of the Caris Precision Oncology Alliance, Caris LifeSciences, Phoenix, United States of America
18Moores Cancer Center, UCSD, San Diego, United States of America
Find articles by McKay, R. in: JCI | PubMed | Google Scholar
Published April 23, 2024 - More info
Molecular profiling of clear cell RCC (ccRCC) tumors of clinical trial patients has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC (n = 508) and centrally-reviewed nccRCC (n = 149) samples. ccRCC had increased angiogenesis signature scores compared to the heterogeneous group of nccRCC tumors (mean z-score 0.37 vs –0.99, P < 0.001), while cell cycle, fatty acid oxidation (FAO)/AMPK signaling, fatty acid synthesis (FAS)/pentose phosphate signature scores were increased in one or more nccRCC subtypes. Among both ccRCC and nccRCC tumors, T-effector scores statistically correlated with increased immune cell infiltration and were more commonly associated with immunotherapy-related markers (PD-L1+/TMB-High/MSI-High). In conclusion, this study provides evidence of differential gene transcriptional profiles among ccRCC vs nccRCC tumors, providing new insights for optimizing personalized and histology-specific therapeutic strategies for patients with advanced RCC.