In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression
CS McKimmie, JK Fazakerley - Journal of neuroimmunology, 2005 - Elsevier
The mechanisms that mediate innate immune recognition of CNS infections are unknown.
This study provides a comparison of Toll-like receptor (TLR) gene expression in resting and
virus infected CNS cells. N2a neuroblastoma cells expressed TLR 3 but demonstrated no
change in TLR gene expression in response to either LPS or virus infection. N9 microglia
and differentiated primary astrocytes expressed most TLR genes. TLR 2 expression was
highest in N9 microglia and TLR 7 in astrocytes. In both glial cell types, LPS stimulation …
This study provides a comparison of Toll-like receptor (TLR) gene expression in resting and
virus infected CNS cells. N2a neuroblastoma cells expressed TLR 3 but demonstrated no
change in TLR gene expression in response to either LPS or virus infection. N9 microglia
and differentiated primary astrocytes expressed most TLR genes. TLR 2 expression was
highest in N9 microglia and TLR 7 in astrocytes. In both glial cell types, LPS stimulation …
