Effects of selective cholecystokinin antagonists L364, 718 and L365, 260 on food intake in rats
RD Reidelberger, G Varga, TE Solomon - Peptides, 1991 - Elsevier
The selective type A and B cholecystokinin (CCK) receptor antagonists L364, 718 and L365,
260 were used to identify the receptor subtype that mediates the satiety effect of
endogenous CCK. Male rats (n= 12–13/group), fed ground rat chow ad lib, received L364,
718 (0, 1, 10, 100, or 1000 μg/kg IP) or L365, 260 (0, 0.1, 1, 10, 100, 1000, or 10,000 μg/kg
IP) 2 h after lights off, and food intake was measured 1.5, 3.5, and 5.5 h later. L364, 718
significantly stimulated 1.5-h food intake by more than 40% at 10 μg/kg and higher doses; …
260 were used to identify the receptor subtype that mediates the satiety effect of
endogenous CCK. Male rats (n= 12–13/group), fed ground rat chow ad lib, received L364,
718 (0, 1, 10, 100, or 1000 μg/kg IP) or L365, 260 (0, 0.1, 1, 10, 100, 1000, or 10,000 μg/kg
IP) 2 h after lights off, and food intake was measured 1.5, 3.5, and 5.5 h later. L364, 718
significantly stimulated 1.5-h food intake by more than 40% at 10 μg/kg and higher doses; …
