[HTML][HTML] Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene
E Camerer, JA Røttingen, E Gjernes, K Larsen… - Journal of Biological …, 1999 - ASBMB
Intracellular signaling induced by the coagulation factors (F) VIIa and Xa is poorly
understood. We report here studies on these processes in a human keratinocyte line
(HaCaT), which is a constitutive producer of tissue factor (TF) and responds to both FVIIa
and FXa with elevation of cytosolic Ca 2+, phosphorylation of extracellular signal-regulated
kinase (Erk) 1/2, p38 MAPK, and c-Jun N-terminal kinase, and up-regulation of transcription
of the early growth response gene-1 (egr-1). Using egr-1 as end point, we observed with …
understood. We report here studies on these processes in a human keratinocyte line
(HaCaT), which is a constitutive producer of tissue factor (TF) and responds to both FVIIa
and FXa with elevation of cytosolic Ca 2+, phosphorylation of extracellular signal-regulated
kinase (Erk) 1/2, p38 MAPK, and c-Jun N-terminal kinase, and up-regulation of transcription
of the early growth response gene-1 (egr-1). Using egr-1 as end point, we observed with …
