Gene structure and 5′-flanking regulatory region of the murine serotonin transporter
D Bengel, A Heils, S Petri, M Seemann, K Glatz… - Molecular brain …, 1997 - Elsevier
By modulating the magnitude and duration of postsynaptic responses, carrier-facilitated
serotonin (5-HT) transport into and release from the presynaptic neuron is central to the fine
tuning of serotonergic neurotransmission. The 5-HT transporter (5-HTT) is the prime target
for widely used antidepressants, psychostimulants, drugs of abuse and neurotoxins. We
have isolated the gene encoding the murine 5-HTT and determined the sequence of all
exons including adjacent intronic regions and∼ 3.6 kb of the 5′-flanking regulatory region …
serotonin (5-HT) transport into and release from the presynaptic neuron is central to the fine
tuning of serotonergic neurotransmission. The 5-HT transporter (5-HTT) is the prime target
for widely used antidepressants, psychostimulants, drugs of abuse and neurotoxins. We
have isolated the gene encoding the murine 5-HTT and determined the sequence of all
exons including adjacent intronic regions and∼ 3.6 kb of the 5′-flanking regulatory region …
