Acetazolamide and amiloride inhibit pentobarbital-induced facilitation of nocifensive reflexes
DP Archer, S Roth - The Journal of the American Society of …, 1999 - pubs.asahq.org
Background Neuronal excitation may result from stimulation of gamma-aminobutyric acid A
(GABA (A)) receptors that prolong the channel opening, depolarizing the postsynaptic
membrane. Drugs such as acetazolamide or amiloride can block GABA depolarization.
Barbiturates facilitate nociceptive reflexes and also prolong the GABA (A) channel open-
time. To evaluate the possible mechanism, the authors studied the impact of acetazolamide
and amiloride on pentobarbital-induced nocifensive reflex facilitation. Because nitric oxide …
(GABA (A)) receptors that prolong the channel opening, depolarizing the postsynaptic
membrane. Drugs such as acetazolamide or amiloride can block GABA depolarization.
Barbiturates facilitate nociceptive reflexes and also prolong the GABA (A) channel open-
time. To evaluate the possible mechanism, the authors studied the impact of acetazolamide
and amiloride on pentobarbital-induced nocifensive reflex facilitation. Because nitric oxide …