[HTML][HTML] Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3
I Ishii, B Friedman, X Ye, S Kawamura… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its
cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals:
LP B1/EDG-1, LP B2/H218/AGR16/EDG-5, LP B3/EDG-3, LP B4/NRG-1/EDG-8, and LP
C1/EDG-6. One of these receptors, LP B1, has recently been shown to be essential for
mouse embryonic development. Here we disrupted the lp B3 gene in mice, resulting in the
complete absence of lp B3 gene, transcript, and LP B3 protein. LP B3-null mice were viable …
cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals:
LP B1/EDG-1, LP B2/H218/AGR16/EDG-5, LP B3/EDG-3, LP B4/NRG-1/EDG-8, and LP
C1/EDG-6. One of these receptors, LP B1, has recently been shown to be essential for
mouse embryonic development. Here we disrupted the lp B3 gene in mice, resulting in the
complete absence of lp B3 gene, transcript, and LP B3 protein. LP B3-null mice were viable …