Myostatin is a negative regulator of muscle growth. Loss of myostatin has been shown to
cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in
the dystrophin-deficient mdx muscular dystrophy mouse model. We evaluated whether lack
of myostatin has an impact on cardiac muscle growth and fibrosis in vivo. Using genetically
modified mice we assessed whether myostatin absence induces similar beneficial effects on
cardiac function and fibrosis. Cardiac mass and ejection fraction were measured in wild …