[HTML][HTML] Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation
M Sharma, WW Chuang, Z Sun - Journal of Biological Chemistry, 2002 - ASBMB
PI3K/Akt plays a critical role in prostate cancer cell growth and survival. Recent studies have
shown that the effect of PI3K/Akt in prostate cells is mediated through androgen signaling.
The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the
PI3K/Akt pathway and repress AR activity. However, the molecular mechanisms whereby
PI3K/Akt and PTEN regulate the androgen pathway are currently unclear. Here, we
demonstrate that blocking the PI3K/Akt pathway reduces the expression of an endogenous …
shown that the effect of PI3K/Akt in prostate cells is mediated through androgen signaling.
The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the
PI3K/Akt pathway and repress AR activity. However, the molecular mechanisms whereby
PI3K/Akt and PTEN regulate the androgen pathway are currently unclear. Here, we
demonstrate that blocking the PI3K/Akt pathway reduces the expression of an endogenous …
