Nuclear import and export signals in control of Nrf2
AK Jain, DA Bloom, AK Jaiswal - Journal of Biological Chemistry, 2005 - ASBMB
Nrf2 binds to the antioxidant response element and regulates expression and antioxidant
induction of a battery of chemopreventive genes. In this study, we have identified nuclear
import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is
regulated by antioxidants. We demonstrate that Nrf2 contains a bipartite nuclear localization
signal (NLS) and a leucine-rich nuclear export signal, which regulate Nrf2 shuttling in and
out of the nucleus. Immunofluorescence and immunoblot analysis revealed that Nrf2 …
induction of a battery of chemopreventive genes. In this study, we have identified nuclear
import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is
regulated by antioxidants. We demonstrate that Nrf2 contains a bipartite nuclear localization
signal (NLS) and a leucine-rich nuclear export signal, which regulate Nrf2 shuttling in and
out of the nucleus. Immunofluorescence and immunoblot analysis revealed that Nrf2 …
