As early as the 19th century, OIH was observed in patients receiving morphine for pain. It was recognized that a potent analgesic such as morphine could actually result in an increase in pain and was observed by Albutt in 1870 (18). Albutt described that,“At such times I have certainly felt it a great responsibility to say that pain, which I know is an evil, is less injurious than morphia, which may be an evil.” It was questioned that,“Does morphia tend to encourage the very pain it pretends to relieve? In addition, Albutt stated that,“Experience is needed” and,“... in the cases in question, I have much reason to suspect that a reliance upon hypodermic morphia only ended in that curious state of perpetuated pain.”