Transgenic and gene knock-out studies demonstrated that the mouse Forkhead Box m1
(Foxm1 or Foxm1b) transcription factor (previously called HFH-11B, Trident, Win, or MPP2)
is essential for hepatocyte entry into mitosis during liver development, regeneration, and
liver cancer. Targeted deletion of Foxm1 gene in mice produces an embryonic lethal
phenotype due to severe abnormalities in the development of liver and heart. In this study,
we show for the first time that Foxm1–/–lungs exhibit severe hypertrophy of arteriolar smooth …