[HTML][HTML] Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting 2
N Melzer, C Villmann, K Becker, K Harvey… - Journal of biological …, 2010 - ASBMB
The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated ion channel that mediates
fast synaptic inhibition in the vertebrate central nervous system. As a member of the family of
Cys-loop receptors, it assembles from five homologous subunits (GlyRα1–4 and-β). Each
subunit contains an extracellular ligand binding domain, four transmembrane domains (TM),
and an intracellular domain, formed by the loop connecting TM3 and TM4 (TM3–4 loop). The
TM3–4 loops of the subunits GlyRα1 and-α3 harbor a conserved basic motif, which is part of …
fast synaptic inhibition in the vertebrate central nervous system. As a member of the family of
Cys-loop receptors, it assembles from five homologous subunits (GlyRα1–4 and-β). Each
subunit contains an extracellular ligand binding domain, four transmembrane domains (TM),
and an intracellular domain, formed by the loop connecting TM3 and TM4 (TM3–4 loop). The
TM3–4 loops of the subunits GlyRα1 and-α3 harbor a conserved basic motif, which is part of …
