[HTML][HTML] Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of …
FK Racke, K Lewandowska, S Goueli… - Journal of Biological …, 1997 - ASBMB
The extracellular signal-regulated kinase (ERK), originally identified as a participant in
mitogenic signaling, has recently been implicated in the signaling of cellular differentiation.
To examine the role of the ERK/MAP kinase pathway in megakaryocytic differentiation of
K562 cells, the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and bryostatin on
ERK activation were determined. Both TPA and bryostatin are known to activate PKC but
paradoxically have opposing effects on megakaryocytic differentiation. TPA, a differentiation …
mitogenic signaling, has recently been implicated in the signaling of cellular differentiation.
To examine the role of the ERK/MAP kinase pathway in megakaryocytic differentiation of
K562 cells, the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and bryostatin on
ERK activation were determined. Both TPA and bryostatin are known to activate PKC but
paradoxically have opposing effects on megakaryocytic differentiation. TPA, a differentiation …
