[HTML][HTML] Stochastic fate selection in HIV-infected patients
AD Weinberger, LS Weinberger - Cell, 2013 - cell.com
Cell, 2013•cell.com
Classic studies proposed that stochastic variability (" noise") can drive biological fate
switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from
dormant (latently infected) patient cells—the major barrier to an HIV cure—is inherently
stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require
inventive approaches.
switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from
dormant (latently infected) patient cells—the major barrier to an HIV cure—is inherently
stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require
inventive approaches.
Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells—the major barrier to an HIV cure—is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.
cell.com