Late onset of obesity in male androgen receptor-deficient (AR KO) mice
T Sato, T Matsumoto, T Yamada, T Watanabe… - Biochemical and …, 2003 - Elsevier
T Sato, T Matsumoto, T Yamada, T Watanabe, H Kawano, S Kato
Biochemical and biophysical research communications, 2003•ElsevierAn androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P
system. The male (ARL−/Y)(KO) mice exhibited typical features of testicular feminization
mutant (Tfm) disease in external reproductive organs with growth retardation. The growth
curve of the male AR KO mice was similar to that of the wild-type female littermates until the
10th week of age, but thereafter a drastic increase in the growth was observed with
development of obesity. Clear increase in the wet weights of white adipose tissues, but not …
system. The male (ARL−/Y)(KO) mice exhibited typical features of testicular feminization
mutant (Tfm) disease in external reproductive organs with growth retardation. The growth
curve of the male AR KO mice was similar to that of the wild-type female littermates until the
10th week of age, but thereafter a drastic increase in the growth was observed with
development of obesity. Clear increase in the wet weights of white adipose tissues, but not …
An androgen receptor (AR) null mutant mice line was generated by means of a Cre-lox P system. The male (ARL−/Y) (KO) mice exhibited typical features of testicular feminization mutant (Tfm) disease in external reproductive organs with growth retardation. The growth curve of the male AR KO mice was similar to that of the wild-type female littermates until the 10th week of age, but thereafter a drastic increase in the growth was observed with development of obesity. Clear increase in the wet weights of white adipose tissues, but not of brown adipose tissue, was found in the 30-week-old male AR KO mice. However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males.
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