Abstract Angiopoietin-1 (Ang-1) stimulates endothelial and vascular network differentiation
through the Tie-2 receptor tyrosine kinase, while Ang-2 modulates this activation in embryo
and tumor growth. The nephrogenic pattern of Ang-2 was documented in a mouse strain that
expresses the LacZ reporter gene driven by the Ang-2 promoter. Heterozygous animals
were healthy with morphologically normal kidneys, and they were examined after X-gal
staining. At embryonic days 10.5 (E10. 5) and E12. 0, transgene expression was absent in …