Critical nodes in signalling pathways: insights into insulin action
Nature reviews Molecular cell biology, 2006•nature.com
Physiologically important cell-signalling networks are complex, and contain several points of
regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the
concept of'critical nodes' to define the important junctions in these pathways and illustrate
their unique role using insulin signalling as a model system.
regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the
concept of'critical nodes' to define the important junctions in these pathways and illustrate
their unique role using insulin signalling as a model system.
Abstract
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
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