The Th17/Treg balance is disturbed during aging

V Schmitt, L Rink, P Uciechowski - Experimental gerontology, 2013 - Elsevier
Aging is associated with multiple changes in the proliferative and functional abilities of the
immune system which are not related to any pathology but consequences in
immunosenescence and inflammaging. T helper (TH) 17 cells have been implicated in the
development of autoimmune and chronic inflammatory diseases in humans. Additionally, a
reciprocal relationship between these pro-inflammatory TH 17 and the anti-inflammatory
regulatory T cells (Tregs) has been described. Recent studies reported an increase of TH 17 …