The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system
AE Adriaenssens, FM Gribble, F Reimann - Peptides, 2020 - Elsevier
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone released from
the epithelium of the upper small intestine. While GIP shares common actions on the
pancreatic beta cell with glucagon-like peptide-1 (GLP-1), unlike GLP-1, GIP presents a
complex target for the development of diabetes and obesity therapies due to its extra-
pancreatic effects on fat mass. Recent pharmacological developments, however, have
provided insight into a previously unrecognized role for GIP receptor (GIPR) signaling in …
the epithelium of the upper small intestine. While GIP shares common actions on the
pancreatic beta cell with glucagon-like peptide-1 (GLP-1), unlike GLP-1, GIP presents a
complex target for the development of diabetes and obesity therapies due to its extra-
pancreatic effects on fat mass. Recent pharmacological developments, however, have
provided insight into a previously unrecognized role for GIP receptor (GIPR) signaling in …