Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate for rAd5-FMDV vaccines in …
NA Montiel, G Smoliga, J Arzt - Veterinary immunology and …, 2013 - Elsevier
Replication-defective recombinant adenovirus 5 (rAd5) vectors carrying foot-and-mouth
disease virus (FMDV) transgenes elicit a robust immune response to FMDV challenge in
cattle; however mechanistic functions of vaccine function are incompletely understood.
Recent efforts addressing critical interactions of rAd5 vectors with components of the bovine
immune system have elucidated important aspects of induction of protective immunity
against FMDV. In the current study, a rAd5-Luciferase (rAd5-Luc) surrogate vector was …
disease virus (FMDV) transgenes elicit a robust immune response to FMDV challenge in
cattle; however mechanistic functions of vaccine function are incompletely understood.
Recent efforts addressing critical interactions of rAd5 vectors with components of the bovine
immune system have elucidated important aspects of induction of protective immunity
against FMDV. In the current study, a rAd5-Luciferase (rAd5-Luc) surrogate vector was …
