Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
M Sebode, M Peiseler, B Franke, D Schwinge… - Journal of …, 2014 - Elsevier
Background & Aims Recently, genome wide association studies in primary sclerosing
cholangitis (PSC) revealed associations with gene polymorphisms that potentially could
affect the function of regulatory T cells (Treg). The aim of this study was to investigate Treg in
patients with PSC and to associate their numbers with relevant gene polymorphisms.
Methods Treg frequency in blood was assessed by staining for CD4+ CD25 high FOXP3+
CD127 low lymphocytes and determination of Treg-specific FOXP3 gene locus …
cholangitis (PSC) revealed associations with gene polymorphisms that potentially could
affect the function of regulatory T cells (Treg). The aim of this study was to investigate Treg in
patients with PSC and to associate their numbers with relevant gene polymorphisms.
Methods Treg frequency in blood was assessed by staining for CD4+ CD25 high FOXP3+
CD127 low lymphocytes and determination of Treg-specific FOXP3 gene locus …