Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related to IL-12 signaling
D Schwinge, F von Haxthausen, A Quaas… - Journal of …, 2017 - Elsevier
Background & Aims Reduced numbers of regulatory T cells (Treg) have been reported in
patients with primary sclerosing cholangitis (PSC); therefore, Treg expansion might serve as
a therapeutic approach. Here, we explored whether treatment with IL-2/IL-2 monoclonal
antibody complex (IL-2/IL-2Ab complex) could provide in vivo Treg expansion and treatment
of experimental sclerosing cholangitis. Methods Treg were expanded by repeated injection
of IL-2/IL-2Ab complex in mouse models of cholangitis (Mdr2−/−, DDC) or colitis (dextran …
patients with primary sclerosing cholangitis (PSC); therefore, Treg expansion might serve as
a therapeutic approach. Here, we explored whether treatment with IL-2/IL-2 monoclonal
antibody complex (IL-2/IL-2Ab complex) could provide in vivo Treg expansion and treatment
of experimental sclerosing cholangitis. Methods Treg were expanded by repeated injection
of IL-2/IL-2Ab complex in mouse models of cholangitis (Mdr2−/−, DDC) or colitis (dextran …