[HTML][HTML] Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
M Reich, L Spomer, C Klindt, K Fuchs, J Stindt… - Journal of …, 2021 - Elsevier
Abstract Background&Aims Primary sclerosing cholangitis (PSC) is characterized by chronic
inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is
found on biliary epithelial cells (BECs), where it promotes secretion, proliferation and tight
junction integrity. Thus, we speculated that changes in TGR5-expression in BECs may
contribute to PSC pathogenesis. Methods TGR5-expression and-localization were analyzed
in PSC livers and liver tissue, isolated bile ducts and BECs from Abcb4-/-, Abcb4-/-/Tgr5 Tg …
inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is
found on biliary epithelial cells (BECs), where it promotes secretion, proliferation and tight
junction integrity. Thus, we speculated that changes in TGR5-expression in BECs may
contribute to PSC pathogenesis. Methods TGR5-expression and-localization were analyzed
in PSC livers and liver tissue, isolated bile ducts and BECs from Abcb4-/-, Abcb4-/-/Tgr5 Tg …